From Longman Dictionary of Contemporary Englishunhingeun‧hinge /ʌnˈhɪndʒ/ verb [transitive] CRAZYto make someone become very upset or mentally ill The terrible experience seemed to have unhinged him slightly. —unhinged adjective→ See Verb table
Examples from the Corpus
unhinge• Although Kazrik survived, the experienced has unhinged him somewhat.• The stress of the job has unhinged many workers. 